Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites
Mengmeng Fan, Liping Hu, Shengmin Shi, Xiaomeng Song, Huan He, Baohui Qi
Topics & Concepts
ChemistryT790MAllosteric regulationEGFR inhibitorsPharmacologyMutantDocking (animal)StereochemistryKinaseQuinazolineBiochemistryEpidermal growth factor receptorEnzymeReceptorGeneMedicineGefitinibNursingLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications