Unlocking Regiodivergence in Pd<sup>II</sup>- and Rh<sup>III</sup>-Mediated Site-Selective C–H Bond Alkynylation of Imidazopyridines
Qiang Zhang, Xuecong Huang, Yuting Gui, Youyuan He, Siyang Liao, Guan Huang, Taoyuan Liang, Zhuan Zhang
Abstract
An efficient Pd II - and Rh III -controlled site-selective C–H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is disclosed. The divergent methodology allows straightforward access to a wide range of products alkynylated at the C3 and ortho positions. This strategy is suggestive of a practical platform that can be suitable for late-stage diversification and may assist in the design of more selective and complementary catalytic systems.
Topics & Concepts
AlkynylationChemistryCatalysisPalladiumCombinatorial chemistryRange (aeronautics)StereochemistryOrganic chemistryComposite materialMaterials scienceCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions