An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway
Jingyao Chen, Lei Zhao, Hongling Peng, Siqi Dai, Yuan Quan, Manli Wang, Jian Wang, Zhanying Bi, Ying Zheng, Shengtao Zhou, Yu Liu, Chong Chen, Feifei Na
Topics & Concepts
OrganoidCancer researchEndometrial cancerHIF1ABiologyMEN1CancerTranscriptomeCell biologyGene expressionAngiogenesisGeneGeneticsMultiple endocrine neoplasiaHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationProtein Degradation and Inhibitors