Transplantation of alveolar macrophages improves the efficacy of endothelial progenitor cell therapy in mouse model of bronchopulmonary dysplasia
Afzaal Nadeem Mohammed, Fatemeh Kohram, Ying‐Wei Lan, Enhong Li, Olena A. Kolesnichenko, Tanya V. Kalin, Vladimir V. Kalinichenko
2024American Journal of Physiology-Lung Cellular and Molecular Physiology8 citationsDOIOpen Access PDF
Abstract
Recent studies demonstrated that transplantation of lung-resident endothelial progenitor cells (EPC) is an effective therapy in mouse model of bronchopulmonary dysplasia (BPD). However, key factors regulating the efficacy of EPC are unknown. Herein, we demonstrate that transplantation of tissue-resident alveolar macrophages (rAM) increases CXCL12 expression in neonatal mouse lungs. rAM are required for retention of donor EPC in hyperoxia-injured lungs. Co-transplantation of rAM and EPC improves the efficacy of EPC therapy in mouse BPD model.
Topics & Concepts
Bronchopulmonary dysplasiaHyperoxiaProgenitor cellAdoptive cell transferMedicineTransplantationCell therapyLungImmunologyMacrophageStem cellCancer researchPathologyBiologyInternal medicineCell biologyT cellImmune systemGestational agePregnancyIn vitroBiochemistryGeneticsNeonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia StudiesRespiratory Support and Mechanisms