Simple and Fast Determination of Piroxicam in Pharmaceutical and Real Samples Using Glassy Carbon Electrode Modified with Copper Nano-particles
Azizallah Feizollahi, Amir Abbas Rafati, Parnaz Assari, Roghayeh Asadpour Joghani
Abstract
In this work, piroxicam concentration measurements in pharmaceutical products and real samples were carried out using glassy carbon electrode modified with copper nanoparticles. The CuNPs/GCE has a high sensitivity, fast response and suitability lifetime in respect to electro-oxidation and determination of piroxicam. The electro-oxidation of piroxicam showed dependency on the pH changes (3–8) of supporting electrolyte, and pH 7 was selected as an optimum value. The behavior of fabricated modified electrode was checked as a sensitive detection method for determination of piroxicam using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Under optimal conditions, DPV technique was used for determination of piroxicam within 3 to 135 μ m by modified electrode with a low detection limit of 0.22 μ m (for S/N = 3) and sensitivity of about 0.061 μ A μ m −1 m −2 . The determination of piroxicam in pharmaceutical products without any interference of excipients in the formulations and foreigner species in real samples, resulted in an acceptable deviation from the mentioned concentrations.