N-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa
Caleb Nketia Mensah, Gilbert Boadu Ampomah, Jehoshaphat Oppong Mensah, Edward Ntim Gasu, Caleb Impraim Aboagye, Edmund Ekuadzi, Nathaniel Owusu Boadi, Lawrence Sheringham Borquaye
Abstract
PAO1. The binding affinity of the compounds with LasR followed a similar trend as that observed in the QS inhibitory assays, suggesting that interaction with LasR may be important for QS inhibition.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaMicrobiologyChemistryBiologyBiofilmBacteriaGeneticsBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesBiochemical and Structural Characterization