Androgen receptor activity in T cells limits checkpoint blockade efficacy
Xiangnan Guan, Fanny Polesso, Chaojie Wang, Archana Sehrawat, Reed M. Hawkins, Susan Murray, George Thomas, Breanna Caruso, Reid F. Thompson, Mary A. Wood, Christina Hipfinger, Scott A. Hammond, Julie N. Graff, Zheng Xia, Amy E. Moran
Topics & Concepts
BlockadeAndrogen receptorImmunotherapyCancer researchProstate cancerCD8Immune checkpointT cellCytokineCytotoxic T cellMedicineCancer immunotherapyReceptorImmune systemPharmacologyBiologyCancerInternal medicineImmunologyBiochemistryIn vitroCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction