Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses
Xin Lin, Nicole M. Fisher, Shalini Dogra, Rebecca K. Senter, Carson W. Reed, Jacob J. Kalbfleisch, Craig W. Lindsley, Wesley B. Asher, Zixiu Xiang, Colleen M. Niswender, Jonathan A. Javitch
Abstract
heterodimers are a key molecular target for modulating the activity of hippocampal SC-CA1 synapses.
Topics & Concepts
Schaffer collateralMetabotropic glutamate receptorMetabotropic glutamate receptor 7Metabotropic glutamate receptor 2Allosteric regulationNeuroscienceMetabotropic glutamate receptor 1Excitatory postsynaptic potentialGlutamate receptorMetabotropic receptorChemistryBiologyReceptorBiochemistryInhibitory postsynaptic potentialNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchMemory and Neural Mechanisms