Does liquid–liquid phase separation drive peptide folding?
Dean Edun, Meredith R. Flanagan, Arnaldo L. Serrano
Abstract
Two-dimensional infrared spectroscopy reveals folding of an intrinsically disordered peptide when sequestered into a model “membrane-less” organelle.
Topics & Concepts
Fourier transform infrared spectroscopyNucleationDipeptideChemistryFolding (DSP implementation)PeptidePhase (matter)CrystallographyInfraredChemical engineeringBiophysicsChemical physicsChromatographyOrganic chemistryBiochemistryBiologyOpticsPhysicsElectrical engineeringEngineeringRNA Research and SplicingProtein Structure and DynamicsRNA and protein synthesis mechanisms