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The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3β pathway in depressive rats

Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zhu

2022Journal of Affective Disorders11 citationsDOI

Topics & Concepts

LRP1NeurogenesisSynaptic plasticityGene knockdownHippocampal formationCell biologyPI3K/AKT/mTOR pathwayBiologyProtein kinase BNeuroscienceSignal transductionEndocrinologyBiochemistryReceptorLDL receptorLipoproteinCholesterolApoptosisNeurogenesis and neuroplasticity mechanismsStress Responses and CortisolNerve injury and regeneration
The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3β pathway in depressive rats | Litcius