<i>O</i> -Acetylation of Capsular Polysialic Acid Enables <i>Escherichia coli</i> K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of <i>E. coli</i> -Containing Vacuoles in Macrophage-Like Cells
Jinghua Yang, Wei Ma, Yuanyuan Wu, Hui Zhou, Siyu Song, Yuqi Cao, Wang ChengXu, Xiangyuan Liu, Jinwei Ren, Jinyou Duan, Zhichao Pei, Cheng Jin
Abstract
-acetylation of PSA modulated the trafficking of ECVs to prevent them from fusing with lysosomes, enabling them to escape degradation by lysozymes within these cells. Elucidating how subtle modification of the capsule enhances bacterial defenses against host innate immunity will enable the future development of effective drugs or vaccines against infection by E. coli K1.
Topics & Concepts
SIGLECPolysialic acidAcetylationSialic acidMicrobiologyEscherichia coliInnate immune systemStrain (injury)BiologyMacrophageChemistryBiochemistryGeneReceptorCell adhesionIn vitroNeural cell adhesion moleculeCellAnatomyGlycosylation and Glycoproteins ResearchEscherichia coli research studiesImmunotherapy and Immune Responses