Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection
Alicia Marie Healey, Kristina N. Fenner, Colleen O’Dell, B. Paige Lawrence
2024American Journal of Physiology-Lung Cellular and Molecular Physiology11 citationsDOIOpen Access PDF
Abstract
Our study reveals a multifaceted role for aryl hydrocarbon receptor (AHR) signaling in the immune response to coronavirus (CoV) infection. Sustained AHR activation during in vivo mouse CoV infection altered the frequency of mature immune cells in the lung and modulated emergency hematopoiesis, specifically myelopoiesis and megakaryopoiesis, in bone marrow. This provides new insight into immunoregulation by the AHR and extends our understanding of how environmental exposures can impact host responses to respiratory viral infections.
Topics & Concepts
Aryl hydrocarbon receptorImmune systemBone marrowLungReceptorCoronavirusCellImmunologyCoronavirus disease 2019 (COVID-19)Lung infectionMedicineBiologyVirologyChemistryPathologyInternal medicineBiochemistryGeneTranscription factorInfectious disease (medical specialty)DiseaseAir Quality and Health ImpactsEnergy and Environment ImpactsToxic Organic Pollutants Impact