Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable
Miles Horton, HoChan Cheon, Ken R. Duffy, Daniel V. Brown, Shalin H. Naik, Carolina Blanco Alvarado, Joanna R. Groom, Susanne Heinzel, Philip D. Hodgkin
Topics & Concepts
BiologyCytidine deaminaseImmunoglobulin class switchingAffinity maturationCell fate determinationAntibodyPlasma cellB cellGeneticsCell biologyGermlineGeneTranscription factorComputational biologyT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses