Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER stress mediated cell apoptosis and pyroptosis
Tao Wei, Zhiwei Zheng, Xiaoyan Wei, Yugang Liu, Wentao Li, Bingqing Fang, Di Yun, Zhaojun Dong, Baozhu Yi, Wulan Li, Xiaoping Wu, Dezhi Chen, Liping Chen, Jianzhang Wu
Abstract
. In addition, B2 could upregulate the level of reactive oxygen species in lung cancer cells, which in turn activated the endoplasmic reticulum stress and led to cell apoptosis and pyroptosis. Taken together, curcumin analogue B2 is expected to be a novel candidate for lung cancer treatment with improved chemical and biological characteristics.
Topics & Concepts
CurcuminCurcuminoidChemistryApoptosisReactive oxygen speciesLung cancerPyroptosisIn vivoPharmacologyDownregulation and upregulationStereochemistryProgrammed cell deathCancer researchBiochemistryBiologyMedicinePathologyGeneBiotechnologyCurcumin's Biomedical ApplicationsEndoplasmic Reticulum Stress and DiseaseGenomics, phytochemicals, and oxidative stress