BK channel activation by L-type Ca<sup>2+</sup> channels Ca<sub>V</sub>1.2 and Ca<sub>V</sub>1.3 during the subthreshold phase of an action potential
Amber E. Plante, Joshua P. Whitt, Andrea L. Meredith
Abstract
BK K + channels are important regulators of firing. Although Ca 2+ channels are required for their activation in excitable cells, it is not well understood how BK channels activate using these Ca 2+ sources during an action potential. This study demonstrates the differences in BK current activated by Ca V 1.2 and Ca V 1.3 channels in clock neurons and heterologous cells. The results define how specific ion channel partnerships can be engaged during distinct phases of the action potential.
Topics & Concepts
BK channelChemistryBiophysicsPhysicsMembrane potentialBiologyBiochemistryIon channel regulation and functionstochastic dynamics and bifurcationNeuroscience and Neural Engineering