Iridium‐Catalyzed Regio‐ and Enantioselective Borylation of Unbiased Methylene C(sp<sup>3</sup>)−H Bonds at the Position β to a Nitrogen Center
Rongrong Du, Luhua Liu, Senmiao Xu
Abstract
Abstract Reported herein is the pyrazole‐directed iridium‐catalyzed enantioselective borylation of unbiased methylene C−H bonds at the position β to a nitrogen center. The combination of a chiral bidentate boryl ligand, iridium precursor, and pyrazole directing group was responsible for the high regio‐ and enantioselectivity observed. The method tolerated a vast array of functional groups to afford the corresponding C(sp 3 )−H functionalization products with good to excellent enantioselectivity.
Topics & Concepts
BorylationEnantioselective synthesisIridiumChemistryPyrazoleMethyleneDenticityCatalysisLigand (biochemistry)Medicinal chemistryCenter (category theory)StereochemistryCombinatorial chemistryOrganic chemistryCrystal structureCrystallographyArylAlkylBiochemistryReceptorCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions