NIR-triggered biodegradable MOF-coated upconversion nanoparticles for synergetic chemodynamic/photodynamic therapy with enhanced efficacy
Man Zou, Yajie Zhao, Binbin Ding, Fan Jiang, Yeqing Chen, Ping’an Ma, Jun Lin
Abstract
The generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light.
Topics & Concepts
Reactive oxygen speciesPhotodynamic therapyTumor microenvironmentGlutathionePenetration (warfare)NanoparticleChemistryPhoton upconversionBiophysicsPhotochemistryCancer researchMaterials scienceNanotechnologyTumor cellsOptoelectronicsBiochemistryLuminescenceMedicineBiologyEnzymeEngineeringOperations researchOrganic chemistryNanoplatforms for cancer theranosticsLuminescence Properties of Advanced MaterialsAdvanced Nanomaterials in Catalysis