Development of multiple heartcutting two-dimensional liquid chromatography with ion-pairing reversed-phase separations in both dimensions for analysis of impurities in therapeutic oligonucleotides
Dwight R. Stoll, Maria Sylvester, Daniel Meston, Matthew J. Sorensen, Todd D. Maloney
Topics & Concepts
ChemistryChromatographyImpurityReversed-phase chromatographyOligonucleotidePairingHydrophilic interaction chromatographyPhase (matter)High-performance liquid chromatographyAnalytical Chemistry (journal)Organic chemistryBiochemistryDNAQuantum mechanicsPhysicsSuperconductivityAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis ApplicationsProtein purification and stability