Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
Senad Hasanagić, Fadila Serdarević
Abstract
<b>Memantine, as an antagonist of α7-nAChR and NMDA receptors, may decrease ACE2 receptor expression and reduce oxidative stress and inflammation. Hence, memantine may potentially reduce SARS-CoV-2 virulence.</b>https://bit.ly/2AZHiVg
Topics & Concepts
MemantineMedicineAntagonismNMDA receptorPharmacologyReceptorOxidative stressAntagonistReceptor antagonistInflammationAcetylcholineNicotinic agonistCoronavirus disease 2019 (COVID-19)ImmunologyInternal medicineDiseaseInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Pharmacological Receptor Mechanisms and Effects