Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT
Lei Xu, Qiumeng Liu, Hailing Liu, Feimu Fan, Pengcheng Li, Shiwei Yue, Jie Mo, Zhicheng Liu, Renshun Dong, Xuewu Zhang, Hanhua Dong, Huifang Liang, Xiaoping Chen, Bixiang Zhang, Lin Chen, Jin Chen
Topics & Concepts
Protein kinase BHepatocellular carcinomaPhosphorylationCateninContext (archaeology)Cancer researchUbiquitin ligaseUbiquitinRegulatorChemistryBiologySignal transductionCell biologyWnt signaling pathwayBiochemistryGenePaleontologyUbiquitin and proteasome pathwaysRNA modifications and cancerCancer-related gene regulation