Ferroptosis regulates key signaling pathways in gastrointestinal tumors: Underlying mechanisms and therapeutic strategies
Ravichandiran Rabitha, Sethuraman Shivani, Yahya Showket, Ganapasam Sudhandiran
Abstract
, activating transcription factors 3 and 4, are involved in influencing ferroptosis. Importantly, several molecular mediators of ferroptosis, such as p53, nuclear factor erythroid 2-related factor 2/heme oxygenase-1, hypoxia inducible factor 1, and sirtuins, coordinate with ferroptosis in GI cancers. In this review, we elaborated on key molecular mechanisms of ferroptosis and the signaling pathways that connect ferroptosis to GI tumors.
Topics & Concepts
GPX4Cancer researchProgrammed cell deathCell biologyTranscription factorSignal transductionCrosstalkBiologyTumor microenvironmentCancer cellApoptosisCancerOxidative stressSuperoxide dismutaseBiochemistryGlutathione peroxidaseGenePhysicsGeneticsTumor cellsOpticsFerroptosis and cancer prognosisCancer, Lipids, and MetabolismHeme Oxygenase-1 and Carbon Monoxide