Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response
Kanagavel Murugesan, Prasanna Jagannathan, Tho D. Pham, Suchitra Pandey, Hector Bonilla, Karen B. Jacobson, Julie Parsonnet, Jason R. Andrews, Daniela Weiskopf, Alessandro Sette, Benjamin A. Pinsky, Upinder Singh, Niaz Banaei
Abstract
We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4+ T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic.
Topics & Concepts
MedicineImmunologyInterferonCoronavirusVirologyRespiratory systemRespiratory diseasePandemicCoronavirus disease 2019 (COVID-19)DiseaseLungInternal medicineInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing