Focusing on C-4 position of Hantzsch 1,4-dihydropyridines: Molecular modifications, enantioseparation, and binding mechanism to L- and T-type calcium channels
Dilara Akman, Katrin Denzinger, Sun Huang, J.T. Lee, Jordan Nafie, Gerhard Wolber, Gerald W. Zamponi, Daniel W. Armstrong, Miyase Gözde Gündüz
Topics & Concepts
ChemistryDHPSEnantiomerMoietyCalcium channelStereochemistryVoltage-dependent calcium channelSelectivityCombinatorial chemistryL-type calcium channelCalciumMoleculeT-type calcium channelBiochemistryOrganic chemistryPlasmodium falciparumMalariaImmunologyCatalysisBiologyChemical synthesis and alkaloidsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases