Changes and significance of retinal blood oxygen saturation and oxidative stress indexes in patients with diabetic retinopathy
Xiaoli Wang, Fang-Rong Cai, Yun-Xia Gao, Jian Zhang, Ming Zhang
Abstract
BACKGROUND: Diabetic retinopathy (DR) is a diabetic complication that can severely affect the patients' vision, eventually leading to blindness. DR is the most important manifestation of diabetic micro-vasculopathy and is mainly related to the course of diabetes and the degree of blood glucose control, while the age of diabetes onset, sex, and type of diabetes have little influence on it. AIM: To explore the changes in blood oxygen saturation and oxidative stress indices of retinal vessels in patients with DR. METHODS: In total, 94 patients (94 eyes) with DR (DR group) diagnosed at Jianyang people's Hospital between March 2019 and June 2020, and 100 volunteers (100 eyes) (control group) without eye diseases, were included in this study. Arterial and venous blood oxygen saturation, retinal arteriovenous vessel diameter, and serum oxidative stress indicators in the two groups were compared. Based on the stage of the disease, the DR group was divided into the simple DR and proliferative DR groups for stratified analysis. RESULTS: < 0.05). CONCLUSION: Increased blood oxygen saturation of retinal arteries and veins and increased oxidative stress damage in patients with DR may be associated with decreased retinal capillary permeability and arterial oxygen dispersion, possibly reflecting the patient's condition.