Nintedanib treatment for pulmonary fibrosis after coronavirus disease 2019
Hiroaki Ogata, Taisuke Nakagawa, Soichiro Sakoda, Akiko Ishimatsu, Kazuhito Taguchi, Masako Kadowaki, Atsushi Moriwaki, Makoto Yoshida
Abstract
A 78-year-old Japanese woman with no smoking history suffered from near-fatal coronavirus disease 2019 (COVID-19) requiring four-week invasive mechanical ventilation, with subsequent radiological features of pulmonary fibrosis. Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy. In parallel with tapering systemic steroid, the patient was treated with nintedanib. Three months later, the patient was able to walk with a walking aid using oxygen at 4 L/min. The present case is an indication that nintedanib might provide a novel therapeutic approach for managing post-COVID-19 fibrosis, although further studies are warranted.