Immune checkpoint inhibitors in cancer immunotherapy
Megan E. Himmel, Samuel D. Saibil, Alexandra Saltman
Abstract
Tumour cells can evade destruction by the immune system by triggering immune checkpoint receptors, such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1), that are expressed on T-cells and whose engagement inhibit T
Topics & Concepts
Cytotoxic T cellImmune systemImmunotherapyImmune checkpointCTLA-4Programmed cell deathCancer immunotherapyCancer researchPD-L1ImmunologyImmune receptorMedicineT cellBiologyApoptosisBiochemistryIn vitroCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmune cells in cancer