Protein phosphatase 2A-B55β mediated mitochondrial p-GPX4 dephosphorylation promoted sorafenib-induced ferroptosis in hepatocellular carcinoma via regulating p53 retrograde signaling
Bo Qian, Lin Che, Ze‐Bang Du, Nijun Guo, Xin-Mou Wu, Lei Yang, Zhao-Xuan Zheng, Yunlu Gao, Mingzhu Wang, Xiaoxuan Chen, Ling Xu, Zijian Zhou, Yu-Chun Lin, Zhong‐Ning Lin
Abstract
dephosphorylation. Our findings might serve as a potential theranostic strategy to enhance the efficacy of Sora in HCC treatment through the targeted intervention of p-GPX4 dephosphorylation via PP2A-B55β activation.
Topics & Concepts
DephosphorylationPhosphorylationGPX4Cancer researchCell biologyProtein phosphatase 2ChemistryMitochondrionApoptosisBiologyPhosphataseBiochemistryOxidative stressSuperoxide dismutaseGlutathione peroxidaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer