Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer
Nitin Tandon, Vijay Luxami, Divya Kant, Runjhun Tandon, Kamaldeep Paul
Abstract
axitinib, linifanib, niraparib, and pazopanib. Indazole derivatives are applied for the targeted treatment of lung, breast, colon, and prostate cancers. In this review, we compile the current development of indazole derivatives as kinase inhibitors and their application as anticancer agents in the past five years.
Topics & Concepts
IndazolePharmacophoreChemistryCancerKinaseCombinatorial chemistryComputational biologyNanotechnologyComputer scienceBiochemistryMedicineMedicinal chemistryBiologyMaterials scienceInternal medicinePI3K/AKT/mTOR signaling in cancerCancer Mechanisms and TherapyProtein Degradation and Inhibitors