Sustained release of heme–albumin as a potential novel therapeutic approach for age-related macular degeneration
Megan Allyn, María A. Rincon‐Benavides, Heather L. Chandler, Natalia Higuita‐Castro, Andre F. Palmer, Katelyn E. Swindle‐Reilly
Abstract
ROS-responsive polydopamine nanoparticles sustain release of heme–albumin, increasing HO-1 expression in retinal cells, demonstrating a potential therapeutic approach for treatment of inflammatory conditions such as age-related macular degeneration.
Topics & Concepts
HemeOxidative stressHeme oxygenaseReactive oxygen speciesBiliverdinMacular degenerationAlbuminChemistryAntioxidantPharmacologyBiochemistryMedicineOphthalmologyEnzymeHeme Oxygenase-1 and Carbon MonoxideRetinal Diseases and TreatmentsAdvanced Glycation End Products research