Current Perspectives on B Lymphocytes in the Immunobiology of Hepatocellular Carcinoma
Miaomiao Qin, Danping Wang, Yijiao Fang, Zhiying Zheng, Xinyang Liu, Fan Wu, Liangliang Wang, Xiao Li, Bingqing Hui, Shijie Ma, Weiwei Tang, Xiongxiong Pan
Abstract
Immune cells infiltrating tumors are capable of significantly impacting carcinogenesis through cancer promotion and anticancer responses. There are many aspects of hepatocellular carcinoma (HCC) related T lymphocytes that are undergoing extensive studies, whereas the effect exerted by B lymphocytes remains a less researched area. In this study, the latest research on the effect of B lymphocytes as they infiltrate tumors in relation to HCC is presented. Their prognosis-related importance is analyzed, along with their function in the tumor microenvironment (TME), as well as the way that B cell biology can be employed to help create a B cell therapy strategy for HCC.