Deletion of the <i>H240R</i> Gene of African Swine Fever Virus Decreases Infectious Progeny Virus Production Due to Aberrant Virion Morphogenesis and Enhances Inflammatory Cytokine Expression in Porcine Macrophages
Pingping Zhou, Lian‐Feng Li, Kehui Zhang, Bing Wang, Lijie Tang, Miao Li, Tao Wang, Yuan Sun, Su Li, Hua‐Ji Qiu
Abstract
deleted ASFV mutant (ASFV-ΔH240R). More specifically, pH240R directs the morphogenesis of ASFV toward the icosahedral capsid in the process of assembly. In addition, ASFV-ΔH240R infection induced high-level expression of inflammatory cytokines in primary porcine alveolar macrophages. Our results elucidate the role of pH240R in the process of ASFV assembly, which may instruct future research on effective vaccines or antiviral strategies.
Topics & Concepts
African swine fever virusBiologyVirologyVirusCapsidImmunoelectron microscopyDNA virusGeneMolecular biologyAntibodyGenomeGeneticsAnimal Disease Management and EpidemiologyAnimal Virus Infections StudiesViral Infections and Immunology Research