Traceless proton aided regioselective C(sp<sup>2</sup>)–C(sp<sup>2</sup>) construction to synthesize C<sup>6</sup>-acylated purines and purine nucleosides without metal catalysts
Mingwu Yu, Zheng Zhou, Chunhui Zou, Zhichuan Wang, Weili Wang, Kai Sun
Abstract
Expeditious highly C 6 -regioselective acylation of purines and purine nucleosides via a traceless proton aided approach at room temperature without metal catalysts is reported for the first time.
Topics & Concepts
ChemistryRegioselectivityPurine metabolismCatalysisPurineMetalProtonMedicinal chemistryStereochemistryOrganic chemistryEnzymePhysicsNuclear physicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis