Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice
Takashi Mori, Naoki Koyama, Tomotaka Yokoo, Tatsuya Segawa, Masahiro Maeda, Darrell Sawmiller, Jun Tan, Terrence Town
Abstract
transcription. Thus, our data reveal novel post-translational mechanisms for GA. We suggest further examination of GA supplementation in humans will shed light on the exciting therapeutic potential of this molecule.
Topics & Concepts
ADAM10PresenilinAmyloid precursor proteinOxidative stressAmyloid precursor protein secretaseSenile plaquesMorris water navigation taskGenetically modified mouseNeuroinflammationGliosisChemistryCurcuminAlzheimer's diseasePharmacologyTransgeneEndocrinologyBiochemistryInflammationMedicineMetalloproteinaseInternal medicineDisintegrinPathologyEnzymeHippocampusGeneDiseaseAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesMedicinal Plants and Neuroprotection