Structural basis for Cas9 off-target activity
Martin Pacesa, Chun‐Han Lin, Antoine Cléry, Aakash Saha, Pablo Arantes, Katja Bargsten, Matthew J. Irby, Frédéric H.‐T. Allain, Giulia Palermo, Peter Cameron, Paul D. Donohoue, Martin Jínek
Topics & Concepts
Cas9BiologyCRISPRGuide RNAHeteroduplexRNACleaveNucleaseDuplex (building)Computational biologyDNABase pairGenome editingGeneticsNucleic acid structureComplementarity (molecular biology)Cell biologyGeneCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques