<i>ent</i>-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors
Deborah Quaglio, Maria Luisa Mangoni, Roberta Stefanelli, Silvia Corradi, Bruno Casciaro, Valeria Vergine, Federica Lucantoni, Luca Cavinato, Silvia Cammarone, Maria Rosa Loffredo, Floriana Cappiello, Andrea Calcaterra, Silvia Erazo, Francesca Ghirga, Mattia Mori, Francesco Imperi, Fiorentina Ascenzioni, Bruno Botta
Abstract
-beyerane skeleton is identified for the first time as a privileged scaffold for further cost-effective development of valuable colistin resistance inhibitors.
Topics & Concepts
ColistinPseudomonas aeruginosaBacteriaDiterpeneTransferaseEffluxEnzymeBiochemistryChemistryBiologyMicrobiologyAntibioticsGeneticsAntibiotic Resistance in BacteriaBiochemical and Molecular ResearchCancer therapeutics and mechanisms