Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries
Tao Wang, Andrea Wagner, Renate Gehwolf, Wenjin Yan, Fabian S. Passini, Christine B.F. Thien, Nadja Weißenbacher, Zhen Lin, Christine Lehner, Huajian Teng, Claudia Wittner, Qiujian Zheng, Jin Dai, Ming Ni, Allan Wang, J. M. Papadimitriou, Toby Leys, Rocky S. Tuan, Sasha Senck, Jess G. Snedeker, Herbert Tempfer, Qing Jiang, Minghao Zheng, Andreas Traweger
Abstract
, which causes impaired protein secretion and type I collagen fibrillogenesis, is associated with tendon and ligament injuries in patients. Together, our results demonstrate that SPARC is a key extracellular matrix protein essential for load-induced tendon tissue maturation and homeostasis.
Topics & Concepts
TendonHomeostasisExtracellular matrixCell biologyLigamentMedicineAnatomyBiologyTendon Structure and TreatmentLaser Applications in Dentistry and MedicineConnective tissue disorders research