Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities
Gang Li, Jia‐Qiang Wu, Xiaojia Cai, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canqiang Yin, Hongliang Yao
Topics & Concepts
ChemistryTubulinMicrotubuleIC50In vitroCell cyclePolymerizationCell cultureCell cycle checkpointToxicityStereochemistryBiochemistryCombinatorial chemistryCellOrganic chemistryBiologyCell biologyPolymerGeneticsSynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms