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Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Gang Li, Jia‐Qiang Wu, Xiaojia Cai, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canqiang Yin, Hongliang Yao

2023European Journal of Medicinal Chemistry20 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryTubulinMicrotubuleIC50In vitroCell cyclePolymerizationCell cultureCell cycle checkpointToxicityStereochemistryBiochemistryCombinatorial chemistryCellOrganic chemistryBiologyCell biologyPolymerGeneticsSynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms
Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities | Litcius