FGF/FGFR signaling in health and disease
Yangli Xie, Nan Su, Jing Yang, Qiaoyan Tan, Shuo Huang, Min Jin, Zhenhong Ni, Bin Zhang, Dali Zhang, Fengtao Luo, Hangang Chen, Xianding Sun, Jian Q. Feng, Huabing Qi, Lin Chen
Abstract
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.