Oral tofacitinib citrate for recalcitrant cutaneous lupus

Abstract

Cutaneous lupus erythematosus (CLE) is an autoimmune disorder with variable skin manifestations that can occur with or without systemic lupus erythematosus (SLE). While topical agents such as corticosteroids and calcineurin inhibitors for single lesions and systemic agents such as antimalarials, immunomodulators, and immunosuppressants for multiple lesions have demonstrated effectiveness in the treatment of CLE, options are limited when these modalities fail. The limited access to quinacrine in recent years has restricted antimalarial combination use, emphasizing the need for alternative therapies.

Topics & Concepts