Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks
Laura Petersilie, Sonja Heiduschka, Joel S.E. Nelson, Louis A. Neu, Stephanie Le, Ruchika Anand, Karl W. Kafitz, Alessandro Prigione, Christine R. Rose
Abstract
. Overall, cBOS provide a powerful platform to assess morphological and functional aspects of human neural cells in intact minimal networks and to address the pathways that drive cellular damage during brain ischemia.
Topics & Concepts
OrganoidNeuroscienceDisinhibitionInduced pluripotent stem cellHippocampal formationHuman brainNeural stem cellCortical neuronsBiologyChemistryCell biologyStem cellEmbryonic stem cellGeneBiochemistryNeuroscience and Neural EngineeringNeural dynamics and brain functionPhotoreceptor and optogenetics research