Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis
Bo Shi, Wenxia Wang, Benjamin D. Korman, Kai Li, Qianqian Wang, Jun Wei, Swarna Bale, Roberta Gonçalves Marangoni, Swati Bhattacharyya, Stephen D. Miller, Dan Xu, Mahzad Akbarpour, Paul Cheresh, Daniele Proccissi, Demirkan Gursel, Jair Machado Espíndola‐Netto, Claudia C.S. Chini, Guilherme C. de Oliveira, Jóhann E. Guðjónsson, Eduardo N. Chini, John Varga
Abstract
homeostasis as a fundamental mechanism driving fibrosis in SSc, suggesting that CD38 might represent a novel therapeutic target.
Topics & Concepts
NAD+ kinaseCD38FibrosisDownregulation and upregulationSirtuinNicotinamide adenine dinucleotideCancer researchBiologyChemistryCell biologyMedicineImmunologyBiochemistryPathologyEnzymeStem cellGeneCD34Calcium signaling and nucleotide metabolismSirtuins and Resveratrol in MedicineIon Channels and Receptors