Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy
Alexis R. Demonbreun, Katherine S. Fallon, Claire C. Oosterbaan, Lauren A. Vaught, Nina L. Reiser, Elena Bogdanovic, Matthew P. Velez, Isabella M. Salamone, Patrick Page, Michele Hadhazy, Mattia Quattrocelli, David Y. Barefield, Lauren D. Wood, J. Patrick Gonzalez, Carl Morris, Elizabeth M. McNally
Abstract
A high-affinity antibody to LTBP4 stabilizes muscle and promotes improved muscle function in mouse models of muscular dystrophy.
Topics & Concepts
Muscular dystrophyDuchenne muscular dystrophyITGA7mdx mouseMuscle disorderSkeletal muscleBiologyInternal medicineEndocrinologyDystrophinMedicineMuscle Physiology and DisordersMuscle metabolism and nutritionExercise and Physiological Responses