Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening
Chris Payne, Paul Cressey, Anisia Talianu, Elwira Szychot, Darren Hargrave, Maya Thanou, Antonios N. Pouliopoulos
Abstract
. Passive acoustic detection during treatments revealed a correlation between acoustic signal and MRI contrast, providing a scalable metric for assessing clinical treatment efficacy in real-time. In conclusion, therapeutic ultrasound exposure can enhance delivery of large trackable nanoparticles into the brain, while enabling real-time treatment monitoring and verification.
Topics & Concepts
LiposomeDrug deliveryMicrobubblesBlood–brain barrierNanocarriersBiodistributionNanomedicineMedicineIn vivoBiomedical engineeringFocused ultrasoundDrug delivery to the brainPharmacologyUltrasoundMaterials scienceNanotechnologyCentral nervous systemNanoparticleRadiologyInternal medicineBiologyBiotechnologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingUltrasound Imaging and Elastography