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Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein

Kazuhiro Kobayashi, Wataru Shihoya, Tomohiro Nishizawa, Francois Marie Ngako Kadji, Junken Aoki, Asuka Inoue, Osamu Nureki

2020Nature Structural & Molecular Biology57 citationsDOI

Topics & Concepts

Heterotrimeric G proteinG protein-coupled receptorReceptorTransmembrane domainCell biologyBiophysicsChemistryBiochemistryG proteinBiologyNeuropeptides and Animal PhysiologyReceptor Mechanisms and SignalingNeuroendocrine regulation and behavior
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | Litcius