A greener approach for the synthesis of pyrido[2,3‐<i>d</i>]pyrimidine derivatives in glycerol under microwave heating
Luan A. Martinho, Carlos Kleber Z. Andrade
Abstract
Abstract Herein, we report the multicomponent synthesis of pyrido[2,3‐ d ]pyrimidine derivatives from 6‐aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst‐free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work‐up procedure, and a greener approach compared with other methods reported in the literature.
Topics & Concepts
MalononitrileChemistryPyrimidineGlycerolMicrowave heatingYield (engineering)MicrowaveCatalysisOrganic chemistrySolventGreen chemistryCombinatorial chemistryReaction mechanismStereochemistryMaterials scienceMetallurgyPhysicsQuantum mechanicsMulticomponent Synthesis of HeterocyclesMicrowave-Assisted Synthesis and ApplicationsSynthesis and biological activity