Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients
Samuel Sherng Young Wang, Keefe Chee, Shiun Woei Wong, Guat Bee Tan, Hong Ang, Bernard P. Leung, Chuen Wen Tan, Kollengode Ramanathan, Rinkoo Dalan, Christine Cheung, David Chien Lye, Barnaby Edward Young, Eng Soo Yap, Yew Woon Chia, Bingwen Eugene Fan, The COVID-19 Clotting and Bleeding Investigators
Abstract
<p>COVID-19 associated hypercoagulability and platelet hyperactivity are characteristic of COVID-19 infection and contribute to an increased thrombotic burden. This clinical phenomenon is observed during acute illness and the immediate post-recovery period. In addition to findings of hypercoagulability, endotheliopathy, and inflammation from our previous study of 39 COVID-19 survivors at a time point approximating 1 year after their recovery from COVID-19, we evaluated the platelet activation profile of a subset of 36 patients, demonstrating increased platelet activation with elevated CD36 and P-Selectin expression compared to healthy individuals without COVID-19 infection.</p>