Inactivation of the Response Regulator AgrA Has a Pleiotropic Effect on Biofilm Formation, Pathogenesis and Stress Response in Staphylococcus lugdunensis
Marion Aubourg, Marine Pottier, Albertine Léon, Benoı̂t Bernay, Anne Dhalluin, Margherita Cacaci, Riccardo Torelli, Pierre Ledormand, Cécilia Martini, Maurizio Sanguinetti, Michel Auzou, François Gravey, Jean-Christophe Giárd
Abstract
Although belonging to the natural human skin flora, Staphylococcus lugdunensis is recognized as a particularly aggressive and destructive pathogen. This study aimed to characterize the role of the response regulator AgrA, which is a component of the quorum-sensing agr system and known to be a major element in the regulation of pathogenicity and biofilm formation in Staphylococcus aureus .
Topics & Concepts
AgraVirulenceStaphylococcus lugdunensisQuorum sensingBiologyResponse regulatorBiofilmMutantMicrobiologyAutoinducerRegulatorGeneticsStaphylococcus aureusStaphylococcusGeneBacteriaEcologyAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingMicrobial Metabolism and Applications