Insights into the action of the pharmaceutical metformin: Targeted inhibition of the gut microbial enzyme agmatinase
Lambros J. Tassoulas, Lawrence P. Wackett
Abstract
= 0.6, 0.1, and 0.007 mM, respectively) suggesting a shared mechanism. Agmatine is a known effector of human host metabolism and has been reported to augment metformin's therapeutic effects for type 2 diabetes. This gut-derived inhibition mechanism gives new insights on metformin's action in the gut and may lead to significant discoveries in improving metformin therapy.
Topics & Concepts
MetforminAgmatineMechanism of actionEnzymeGut floraPharmacologyChemistryCatabolismDiabetes mellitusType 2 diabetesBiologyBiochemistryEndocrinologyIn vitroPutrescineGut microbiota and healthProbiotics and Fermented FoodsMetabolism, Diabetes, and Cancer