WS<sub>2</sub> Nanosheets at Noncytotoxic Concentrations Enhance the Cytotoxicity of Organic Pollutants by Disturbing the Plasma Membrane and Efflux Pumps
Peng Yuan, Qixing Zhou, Xiangang Hu
Abstract
nanosheets affected the secondary structure of the efflux pumps and competitively bound with efflux pumps, blocking xenobiotic removal. This work emphasized that TMDCs, especially at the noncytotoxic level, in combination with organic pollutants caused damage that cannot be ignored, providing insight into comprehensive safety assessment and the specific toxicological mechanisms of TMDCs that accompany organic pollutant exposure.
Topics & Concepts
PollutantEffluxChemistryTriclosanMembraneEnvironmental chemistryCytotoxicityOrganic chemistryBiochemistryMedicinePathologyIn vitroAdvanced biosensing and bioanalysis techniquesGraphene and Nanomaterials ApplicationsMicroplastics and Plastic Pollution