Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference
Si Liu, Yanhong Han, Wanxiang Li, Shou‐Wei Ding
Abstract
Immune recognition of viral genome-derived double-stranded RNA (dsRNA) molecules and their subsequent processing into small interfering RNAs (siRNAs) in plants, invertebrates, and mammals trigger specific antiviral immunity known as antiviral RNA interference (RNAi). Immune sensing of viral dsRNA is sequence-independent, and most regions of viral RNAs are targeted by virus-derived siRNAs which extensively overlap in sequence.
Topics & Concepts
BiologyRNA silencingRNA interferenceRNASmall interfering RNATrans-acting siRNAVirologyDNA-directed RNA interferenceVirusDNAGeneticsGenePlant Virus Research StudiesRNA Interference and Gene DeliveryAnimal Virus Infections Studies